June 27, 2019
Congratulations, Karl (and all coauthors) to your Nature Communication paper!
In close collaboration with Edouard Bertrand (IgMM, CNRS, Montpellier) and Rob Singer (Albert Einstein College, USA), we performed live cell imaging using a much improved MS2 system to reveal 3’-UTR dependent mRNA sorting to synapses. Karl could demonstrate dynamic mRNA recruitment to active synapses thereby providing strong experimental support to the Sushi belt model for RNA trafficking in neurons.
Furthermore, Karl’s work represents a milestone in unraveling the molecular mechanisms representing a first molecular correlate of learning and memory at the synaptic level.
Transport of Rgs4 mRNA (green) to a synapse (magenta) in the dendrites of a hippocampal neuron (size bar: 10 µm). Picture: Karl Bauer