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June 29, 2021

rico_cellreports2021_130x100 Rico et al. could demonstrate that Staufen2 primarily controls mRNA levels and thereby the amount of proteins they encode. Pumilio2, on the other hand, regulates directly mRNA translation, in particular the expression of key GABAergic synaptic components. In conclusion, both RBPs modulate different aspects of synaptic transmission. Thereby, they are complementing each other in order to maintain balanced neuronal activity.
Great success, Rico!

Picture courtesy Rico Schieweck