Department of Cell Biology

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Annette Müller-Taubenberger

Filamin A promotes efficient migration and phagocytosis of neutrophil-like HL-60 cells.
Roth H, Samereier M, Begandt D, Pick R, Salvermoser M, Brechtefeld D, Schleicher M,
Walzog B, Müller-Taubenberger A.  
Eur J Cell Biol. 2017 May 27. pii: S0171-9335(16)30296-5. doi: 10.1016/j.ejcb.2017.05.004. [Epub ahead
of print] PubMed PMID: 28595776.

EB1 contributes to proper front-to-back polarity in neutrophil-like HL-60 cells.
Samereier M, Schleicher M, Roth H, Brechtefeld D, Walzog B, Müller-Taubenberger A.  
Eur J Cell Biol. 2017 Mar;96(2):143-153. doi:10.1016/j.ejcb.2017.01.006. Epub 2017 Jan 19.
PubMed PMID: 28132723.

Actin-Interacting Protein 1 Contributes to Intranuclear Rod Assembly in Dictyostelium discoideum.
Ishikawa-Ankerhold HC, Daszkiewicz W, Schleicher M, Müller-Taubenberger A.
Sci Rep. 2017 Jan 11;7:40310. doi: 10.1038/srep40310.PubMed PMID: 28074884;
PubMed Central PMCID: PMC5225641.

Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells.
Lange M, Prassler J, Ecke M, Müller-Taubenberger A, Gerisch G.  
J Cell Sci. 2016 Sep 15;129(18):3462-72. doi:10.1242/jcs.191148. Epub 2016 Aug 5. PubMed PMID: 27505897.

Balanced cortical stiffness is important for efficient migration of Dictyostelium cells in confined environments.
Roth H., Samereier M., Trommler G, Noegel AA, Schleicher M, Müller-Taubenberger A.
Biochem Biophys Res Commun. 2015 Oct 16. pii: S0006-291X(15)30772-5. doi: 10.1016/j.bbrc.2015.10.073. [Epub ahead of print] 

Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins.
Swaminathan K, Stumpf M, Müller R, Horn AC, Schmidbauer J, Eichinger L, Müller-Taubenberger A, Faix J, Noegel AA.
Sci Rep. 2015 Sep 28;5:14437. doi: 10.1038/srep14437.

Regulation of a LATS-homolg by Ras GTPases is important for the control of cell division
Annette Müller-Taubenberger, Peter M Kastner, Michael Schleicher, Parvin Bolourani and Gerald Weeks
BMC Cell Biology 2014, 15:25 doi:10.1186/1471-2121-15-25.

The Dictyostelium discoideum RACK1 orthologue has roles in growth and development
Omosigho NN, Swaminathan K, Plomann M, Müller-Taubenberger A, Noegel AA1, Riyahi TY.
Cell Commun Signal. 2014 Jun 15;12(1):37. doi: 10.1186/1478-811X-12-37. 

Icm/Dot-dependent inhibition of phagocyte migration by Legionella is antagonized by a translocated Ran GTPase activator
Simon S, Wagner MA, Rothmeier E, Müller-Taubenberger A, Hilbi H
Cell Microbiol. 2014 Jul;16(7):977-92. doi: 10.1111/cmi.12258. Epub 2014 Jan 27.

A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.
Swaminathan K, Müller-Taubenberger A, Faix J, Rivero F, Noegel AA.
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E25-33. doi: 10.1073/pnas.1315368111. Epub 2013 Dec 17. 

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.
Rothmeier E, Pfaffinger G, Hoffmann C, Harrison CF, Grabmayr H, Repnik U, Hannemann M, Wölke S, Bausch A, Griffiths G, Müller-Taubenberger A, Itzen A, Hilbi H. 
PLoS Pathog. 2013 Sep;9(9):e1003598. doi: 10.1371/journal.ppat.1003598. Epub 2013 Sep 19. 

Aberrant spindle dynamics and cytokinesis in Dictyostelium discoideum cells that lack glycogen synthase
kinase 3

Adrian J Harwood, Josephine E Forde-Thomas, Hazel Williams, Matthias Samereier, Annette Müller-Taubenberger
Eur J Cell Biol. 2013 Jun-Jul;92(6-7):222-8. doi: 10.1016/j.ejcb.2013.05.001. Epub 2013 May 16.

A non-mitotic CENP-E homolog in Dictyostelium discoideum with slow motor activity.
Kösem S, Okten Z, Ho TH, Trommler G, Koonce MP, Samereier M, Müller-Taubenberger A.
Biochem Biophys Res Commun. 2013 Feb 15;431(3):490-5. Epub 2013 Jan 16.

Fluorescent reporters and methods to analyze fluorescent signals.
Ishikawa-Ankerhold, H. C. and Müller-Taubenberger, A.
Methods Mol Biol. 2013;983:93-112. doi: 10.1007/978-1-62703-302-2_5.
(2013) Book chapter Methods in Molecular Biology

Simple system – substantial share: The use of Dictyostelium in cell biology and molecular medicineEJCB LogoAnnette Müller-Taubenberger, Arjan Kortholt, Ludwig Eichinger
Eur J Cell Biol. 2013 Feb;92(2):45-53. Epub 2012 Nov 27.

PIP3 Waves and PTEN Dynamics in the Emergence of Cell Polarity.
Gerisch G, Schroth-Diez B, Müller-Taubenberger A, Ecke M. 
Biophys J. 2012 Sep 19;103(6):1170-8 

Curvature recognition and force generation in phagocytosis. 
Clarke, M., Engel., U., Giorgione, J., Müller-Taubenberger, A., Prassler, J., Veltman, D., and G. Gerisch. 2010.
BMC Biol. 2010 Dec 29;8:154

The histone methyltransferase Dot1 is required for DNA damage repair and proper development in Dictyostelium.
Müller-Taubenberger A, Bönisch C, Fürbringer M, Wittek F, Hake SB.
Biochem Biophys Res Commun. 2011 Jan 28;404(4):1016-22. Epub 2010 Dec 25.

The NDR family kinase NdrA of Dictyostelium localizes to the centrosome and is required for efficient phagocytosis.
Kastner, P. M., Schleicher, M., and A. Müller-Taubenberger.
Traffic. 2010 Dec 7.doi: 10.1111/j.1600-0854.2010.01147.x.[Epub ahead of print]

14-3-3 coordinates microtubules, Rac and myosin II to control cell mechanics and cytokinesis.
Zhou, Q., Kee, Y.-S., Poirier, C. C., Jelinek, C., Osborne, J., Divi, S., Surcel, A., Will, M. E., Eggert, U. S., Müller-Taubenberger, A., Iglesias, P. A., Cotter, R. J., and D. N. Robinson. 2010.
Curr. Biol. 20, 1881-1889.

Redundant and unique roles of coronin proteins in Dictyostelium.
Shina, M. C., Müller-Taubenberger, A., Ünal, C., Schleicher, M., Steinert, M., Eichinger, L., Müller, R., Glöckner, G., and A. A. Noegel. 2010.
Cell. Mol. Life Sci. 2011 Jan;68(2):303-13. Epub 2010 Jul 18.

Genetic evidence for concerted control of actin dynamics in cytokinesis, endocytic traffic, Cytoskeleton
and cell motility by coronin and Aip1.

Ishikawa-Ankerhold, H. C., Gerisch, G., and A. Müller-Taubenberger. 2010.
Cytoskeleton 67, 442-455.

Two novel Src homology 2 domain proteins interact to regulate dictyostelium gene expression during growth and early development.
Sugden C, Ross S, Bloomfield G, Ivens A, Skelton J, Mueller-Taubenberger A, Williams JG.
J Biol Chem. 2010 Jul 23;285(30):22927-35. Epub 2010 May 10.

A coronin7 homolog with functions in actin-driven processes.
Shina, M. C., Ünal, C., Eichinger, L., Müller-Taubenberger, A., Schleicher, M., Steinert, M., A. A. Noegel. 2010.
J. Biol. Chem. 285, 9249-9261.

The STE group kinase SepA controls cleavage furrow formation in Dictyostelium.
Müller-Taubenberger, A., Ishikawa-Ankerhold, H. C., Kastner, P. M., Burghardt, E., and G. Gerisch.2009.
Cell Motil. Cytoskel. 66, 929-939.

The 3-dimensional dynamics of actin waves, a model for cytoskeletal self-organization.
Bretschneider, T., Anderson, K. I., Ecke, M., Müller-Taubenberger, A., Schroth-Diez, B., Ishikawa-Ankerhold, H. C., and G. Gerisch.
Biophys. J. 96, 2888-2900.

The actinome of Dictyostelium discoideum in comparison to actins and actin-related proteins from other organisms.
Joseph, J., Fey, P., Ramalingam, N., Liu, X. I., Rohlfs, M., Noegel, A. A., Müller-Taubenberger, A., Glöckner, G., and M. Schleicher. 2008
PLoS. ONE 3 (7) e2654.

Overlapping functions of the two talin homologues in Dictyostelium.
Tsujioka, M., Yoshida, K., Nagasaki, A., Yonemura, S, Müller-Taubenberger, A., and T. Q. P. Uyeda. 2008.
Eukaryotic Cell 7, 906-916.

Reversal of cell polarity in the actin cytoskeleton by mechanical and chemical stimuliation.
Dalous, J., Burghardt, E., Müller-Taubenberger, A., Bruckert, F., Gerisch, G., and T. Bretschneider. 2008.
Biophys. J. 94, 1063-1074.

Recent advances using green and red fluorescent proteins variants in cell biological studies.
Müller-Taubenberger, A., and K. I. Anderson. 2007.
Appl. Microbiol. Biotechnol., available online, DOI 10.1007/s00253-007-1131-5.

Asymmetric elastic properties of Dictyostelium discoideum in relation to chemotaxis.
Haupt, B. J., Osbourn, M., Spanhoff, R., de Keijzer, S., Müller-Taubenberger, A., Snaar-Jagalska, E., and T. Schmidt. 2007.
Langmuir 23, 9352-9357.

Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid.
Xu, X., Müller-Taubenberger, A., Adley, K. E., Pawolleck, N., Lee, V. W., Wiedemann, C., Sihra, T. S., Maniak, M., Jin, T., and R. S. B. Williams. 2007.
Eukaryotic Cell 6, 899-906.

Time-resolved responses to chemoattractant, characteristic of the front and tail of Dictyostelium cells.
Etzrodt, M., Ishikawa, H. C. F., Dalous, J., Müller-Taubenberger, A., Bretschneider, T., and G. Gerisch. 2006.
FEBS Lett. 580, 6707-6713.

Actin-mediated rocketing of phagosomes induced by mechanical pressure.
Clarke, M., Müller-Taubenberger, A., Anderson, K. I., Engel, U., and G. Gerisch. 2006.
Mol. Biol. Cell. 17, 4866-4875.

Towards a molecular understanding of human diseases using Dictyostelium discoideum.
Williams, R. S. B., Boeckeler, K., Gräf, R., Müller-Taubenberger, A., Li, Z., Isberg, R. R., Wessels, D., Soll, D. R., Alexander, H., and S. Alexander. 2006.
Trends Mol. Med. 12, 415-424.

The contractile vacuole in Ca2+-regulation in Dictyostelium: its essential function for cAMP-induced Ca2+-influx.
Malchow, D., Lusche, D. F., Schlatterer, C., De Lozanne, A., and A. Müller-Taubenberger. 2006.
BMC Dev. Biol. 6, 31.

Monomeric red fluorescent protein variants used for imaging studies in different species.
Müller-Taubenberger, A., Vos, M. J., Böttger, A., Lasi, M., Lai, F. P. L., Fischer, M., and K. Rottner. 2006.
Eur. J. Cell Biol. 85, 1119-1129.

Visualizing cytoskeleton dynamics in mammalian cells using a humanized variant of monomeric red fluorescent protein.
Fischer, M., Haase, I, Wiesner, S., and A. Müller-Taubenberger. 2006.
FEBS Lett. 580, 2495-2502.

Release of Ca2+ from the endoplasmic reticulum contributes to Ca2+ signaling in Dictyostelium discoideum.
Wilczynska, Z., Happle, K., Müller-Taubenberger, A., Schlatterer, C., Malchow, D., and P. R. Fisher. 2005.
Eukaryotic Cell 4, 1513-1525.

Subsecond reorganization of the actin network in cell motility and chemotaxis.
Diez, S., Gerisch, G., Anderson, K., Müller-Taubenberger, A., and T. Bretschneider. 2005.
Proc. Natl. Acad. Sci. USA 102, 7601-7606.

A brilliant monomeric red fluorescent protein to visualize cytoskeletal proteins in Dictyostelium.
Fischer, M., Haase, I., Simmeth, E., Gerisch, G., and A. Müller-Taubenberger. 2004.
Febs Lett. 577, 227-232.
ISI Citation > 130, Faculty 1000 ‘must read’ factor 7.1

Mobile actin clusters and travelling waves in cells recovering from actin depolymerization.
Gerisch, G., Bretschneider, T., Müller-Taubenberger, A., Simmeth, E., Ecke, M., Diez, S., and K. Anderson. 2004.
Biophys. J. 87, 3493-3503.

Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells.
Bretschneider, T., Diez, S., Anderson, K., Heuser, J., Clarke, M., Müller-Taubenberger, A., Köhler, J., and G. Gerisch. 2004.
Curr. Biol. 14, 1-10.

Actin-binding proteins required for reliable chromosome segregation in mitosis.
Gerisch, G., Faix, J., Köhler, J., and A. Müller-Taubenberger. 2004.
Cell Motil. Cytoskelet. 57, 18-25.

A Lim protein involved in the progression of cytokinesis and regulation of the mitotic spindle.
Schneider, N., Weber, I., Faix, J., Prassler, J., Müller-Taubenberger, A., Köhler, J., Burghardt, E., Gerisch, G., and G. Marriott. 2003.
Cell Motil. Cytoskelet. 56, 130-139.

GFP-fusion proteins as fluorescent reporters to study organelle and cytoskeleton dynamics in chemotaxis and phagocytosis.
Gerisch, G., and A. Müller-Taubenberger. 2003.
Meth. Enzymol. 361, Biophotonics, Part B, 320-337.

Differential localization of the Dictyostelium kinase DPAKa kinase during cytokinesis and cell migration.
Müller-Taubenberger, A., Bretschneider, T., Faix, J., Konzok, A., Simmeth, E., and I. Weber. 2002.
J. Muscle Res. Cell Motil. 23, 751-763.

Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis.
Müller-Taubenberger, A., A. N. Lupas, H. Li, M. Ecke, E. Simmeth, and G. Gerisch. 2001.
EMBO J. 20, 6772-6782.

Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis.
Insall, R., A. Müller-Taubenberger, L. Machesky, J. Köhler, E. Simmeth, S. J. Atkinson, I. Weber, and G. Gerisch. 2001.
Cell Motil. Cytoskel. 50, 115-128.

DAip1, a Dictyostelium homologue of the yeast actin-interacting protein 1, is involved in endocytosis, cytokinesis, and motility.
Konzok, A., I. Weber, E. Simmeth, U. Hacker, M. Maniak, and A. Müller-Taubenberger. 1999.
J. Cell Biol. 146, 453-464.

The contractile vacuole network of Dictyostelium as a distinct organelle: its dynamics visualized by a GFP marker protein.
Gabriel, D., U. Hacker, J. Köhler, A. Müller-Taubenberger, J.-M. Schwartz, M. Westphal, and G. Gerisch. 1999.
J. Cell. Sci. 112, 3995-4005.

Talin-null cells of Dictyostelium are strongly defective in adhesion to particle and substrate surfaces and slightly impaired in cytokinesis.
Niewöhner, J., I. Weber, M. Maniak, A. Müller-Taubenberger, and G. Gerisch. 1997.
J. Cell Biol. 138, 349-361.

A talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant.
Kreitmeier, M., G. Gerisch, C. Heizer, and A. Müller-Taubenberger. 1995.
J. Cell Biol. 129, 179-188.

The pH-sensitive actin-binding protein hisactophilin of Dictyostelium exists in two isoforms which both are myristoylated and distributed between plasma membrane and cytoplasm.
Hanakam, F., C. Eckerskorn, F. Lottspeich, A. Müller-Taubenberger, W. Schäfer, and G. Gerisch. 1995.
J. Biol. Chem. 270, 596-602.

Replacement of the phospholipid-anchor in the contact site A glycoprotein in D. discoideum by a transmembrane region does not impede cell adhesion but reduces residence time on the cell surface.
Barth, A., A. Müller-Taubenberger, P. Taranto, and G. Gerisch. 1994.
J. Cell Biol. 124, 205-215.

Proteasomes from Dictyostelium discoideum: characterization of structure and function.
Schauer, T. M., M. Nesper, M. Kehl, F. Lottspeich, A. Müller-Taubenberger, G. Gerisch, and W. Baumeister. 1993.
J. Struct. Biol. 111, 135-147.

Purification, functional characterization and cDNA sequencing of mitochondrial porin from Dictyostelium discoideum.
Troll, H., D. Malchow, A. Müller-Taubenberger, B. Humbel, F. Lottspeich, M. Ecke, G. Gerisch, A. Schmid, and R. Benz. 1992.
J. Biol. Chem. 267, 21072-21079.

Purification and properties of a secreted and developmentally regulated α-L-fucosidase from Dictyostelium discoideum.
Schopohl, D., A. Müller-Taubenberger, B. Orthen, H. Hess, and W. Reutter. 1992.
J. Biol. Chem. 267, 2400-2405.

Identification of a cis-acting element controlling induction of early gene expression in Dictyostelium discoideum.
May, T., H. Kern, A. Müller-Taubenberger, and W. Nellen. 1989.
Mol. Cell Biol. 9, 4653-4659.

An extended ubiquitin of Dictyostelium is located in the small ribosomal subunit.
Müller-Taubenberger, A., H.-R. Graack, L. Grohmann, M. Schleicher, and G. Gerisch. 1989.
J. Biol. Chem. 264, 5319-5322.

A developmentally regulated gene product from Dictyostelium discoideum shows high homology to human α-L-fucosidase.
Müller-Taubenberger, A., M. Westphal, A. Noegel, and G. Gerisch. 1989.
FEBS Lett. 246, 185-192.

Complete cDNA sequence of a Dictyostelium ubiquitin with a carboxy-terminal tail and identification of the protein using an anti-peptide antibody.
Müller-Taubenberger, A., M. Westphal, E. Jaeger, A. Noegel, and G. Gerisch. 1988.
FEBS Lett. 229, 273-278.

Ubiquitin gene expression in Dictyostelium is induced by heat and cold shock, cadmium, and inhibitors of protein synthesis.
Müller-Taubenberger, A., J. Hagmann, A. Noegel, and G. Gerisch. 1988.
J. Cell Sci. 90, 51-58.

Transcript regulation and carboxyterminal extension of ubiquitin in Dictyostelium discoideum.
Westphal, M., A. Müller-Taubenberger, A. Noegel, and G. Gerisch. 1986.
FEBS Lett. 209, 92-96.

Pattern analysis of gap junction plaques with open and closed pores.
Müller, A., E. W. Blanz, G. Laub, and D. F. Hülser. 1985.
Studia Biophysica 110, 185-192.


Chapters in Books:

Application of fluorescent protein tags as reporters in live cell imaging studies.
Müller-Taubenberger, A. 2006.
In: Dictyostelium discoideum Protocols (eds. L. Eichinger, and F. Rivero-Crespo) Humana Press. Methods Mol. Biol. 346, 229-246.

Dictyostelium discoideum: Cellular slime mold.
Müller-Taubenberger, A., and M. Maniak. 2004.
In: Encyclopedia of Molecular Cell Biology and Molecular Medicine (ed. R. A. Meyers) Wiley-VCH, Weinheim, Vol. 3, 325-349.

Actin-associated proteins in motility and chemotaxis of Dictyostelium cells.
Gerisch, G., R. Albrecht, E. De Hostos, E. Wallraff, C. Heizer, M. Kreitmeier, and A. Müller-Taubenberger. 1993.
In: Cell behaviour: adhesion and motility (eds. G. Jones, D. Wigley, and R. Warn), Cambridge. Soc. Exp. Biol. Symp. 47, 297-315.

Extended ubiquitin in Dictyostelium: an antibody against the carboxyl terminus reacts with a cytoplasmic particulate fraction.
Müller-Taubenberger, A., M. Westphal, A. Noegel, and G. Gerisch. 1988.
In: The ubiquitin system (eds. M. Schlesinger and A. Hershko (eds.), Cold Spring Harbor Laboratory, Cold Spring Harbor, 67-71.



Great lessons told by little cells: The model organism Dictyostelium discoideum. 
Müller-Taubenberger, A.
(2011) Cell News 4

Centrosomen und Zytokinese bei Dictyostelium discoideum.
Müller-Taubenberger, A. and R. Gräf. 2010.
Biospektrum 4.10, 418-422.

From cell-cell adhesion and cellular oscillations to spectacular views inside the cell – 50 years of research with Dictyostelium (Editorial).
Müller-Taubenberger, A. and S. Bozzaro. 2006.
Eur. J. Cell Biol. 85, 851-858.

Visualizing the assembly of actin and actin-Arp2/3 complexes by total internal reflection fluorescence microscopy.
Müller-Taubenberger, A., S. Diez, K. I. Anderson, T. Bretschneider, and G. Gerisch. 2003.
Bio-TecReport T1, Blackwell, 8.